{"created":"2023-05-15T14:59:44.867133+00:00","id":418,"links":{},"metadata":{"_buckets":{"deposit":"cca8d065-723b-4558-9474-a4b9bc8aed24"},"_deposit":{"created_by":9,"id":"418","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"418"},"status":"published"},"_oai":{"id":"oai:kamakura-wu.repo.nii.ac.jp:00000418","sets":["1:57"]},"author_link":["1333","1334"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"26","bibliographicPageStart":"17","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"鎌倉女子大学紀要","bibliographic_titleLang":"ja"},{"bibliographic_title":"The journal of Kamakura Women's University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":" 肺組織損傷部位では、線維芽細胞が増殖し活発にPAI-1を分泌する。このPAI-1は線溶系のuPAと結合してuPA活性を阻害する。線維芽細胞との共培養により、肺胞上皮細胞あるいは血管内皮細胞のuPA受容体であるuPAR産生量、これらの細胞表面におけるuPA活性および遊走を検討した。肺胞上皮細胞、血管内皮細胞表面のuPA活性は線維芽細胞の共存によって抑制されなかったが、uPAR mRNAの発現と遊走は線維芽細胞培養上清添加で刺激された。これらのことから、障害組織で増殖している線維芽細胞が分泌する PAI-1が、肺組織細胞の修復や組織再構築に関わっていると考えられた。\n"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"鎌倉女子大学"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10434900","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"9199780","subitem_source_identifier_type":"ISSN"}]},"item_10002_textarea_24":{"attribute_name":"抄録（英）","attribute_value_mlt":[{"subitem_textarea_value":" In pulmonary tissue injury, fibroblasts proliferate and actively secrete plasminogen activator inhibitor-1 (PAI-1), which inhibits urokinase-type plasminogen activator (uPA) activity. The effect of co-cultivation of lung fibroblasts with human endothelial cells and alveolar epithelial cells on uPA receptor (uPAR) production, as well as surface uPA activity and migration of the latter two types of cells, was examined. Although surface uPA activity of those cells was not significantly suppressed by fibroblasts, their migration and uPAR mRNA expresion were stimulated by the fibroblast-conditioned medium. These results suggested that PAI-1 secreted from proliferating fibroblasts is closely involved in lung tissue repair and remodeling."}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 君子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahashi, Kimiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-30"}],"displaytype":"detail","filename":"高橋　君子 （管理栄養学科）.pdf","filesize":[{"value":"3.5 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"label":"高橋","url":"https://kamakura-wu.repo.nii.ac.jp/record/418/files/高橋　君子 （管理栄養学科）.pdf"},"version_id":"a2fe61a7-99d2-4763-8be2-64e3e88c85d1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"線維芽細胞"},{"subitem_subject":"組織修復"},{"subitem_subject":"細胞遊走"},{"subitem_subject":"ウロキナーゼ型プラスミノーゲンアクチベータ受容体(uPAR)"},{"subitem_subject":"プラスミノーゲンアクチベータインヒビター1(PAI-1)"},{"subitem_subject":"fibroblasts"},{"subitem_subject":"tissue repair"},{"subitem_subject":"migration"},{"subitem_subject":"urokinase-type plasminogen activator receptor(uPAR)"},{"subitem_subject":"plasminogen activator inhibitor-1(PAI-1)"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_title":"肺胞上皮細胞および血管内皮細胞遊走能への肺線維芽細胞共培養の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肺胞上皮細胞および血管内皮細胞遊走能への肺線維芽細胞共培養の影響"},{"subitem_title":"The Presence of Human Pulmonary Fibroblasts Regulates Human Alveolar Epithe1ial and Endothelial Cell Migration"}]},"item_type_id":"10002","owner":"9","path":["57"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-05-08"},"publish_date":"2018-05-08","publish_status":"0","recid":"418","relation_version_is_last":true,"title":["肺胞上皮細胞および血管内皮細胞遊走能への肺線維芽細胞共培養の影響"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2023-07-11T02:51:26.238068+00:00"}